The radiochemistry of platinum

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Cisplatin, carboplatin and oxaliplatin continue to be among the most efficient anticancer drugs in world-wide clinical use so far. Nevertheless, the dose-limiting severe toxic side-effects of platinum-based chemotherapy, the problem of inherent or therapy-induced resistance, the limited activity in a range of tumors, and the meager tumor selectivity are the motivation for tremendous efforts and inventions in the development of novel anticancer platinum drugs.

This article reviews the most recent patents in this field of research, covering the following strategies in the design of promising anticancer platinum complexes: i synthesis of new anticancer platinum complexes, using combinatorial chemistry and high throughput synthesis and screening, ii activation of platinum complexes in the tumor tissue, iii accumulation of platinum complexes at the tumor site, iv novel platinum complexes, displaying activity against cisplatin resistant cells and as inhibitors of specific biological functions, and v direct derivatives of classical anticancer platinum drugs in clinical use.

Keywords: platinum complexes, cisplatin, carboplatin, oxaliplatin, synthesis, novel derivatives, combinatorial chemistry, high throughput synthesis and screening, reduction of side-effects, activation.

Abstract: Cisplatin, carboplatin and oxaliplatin continue to be among the most efficient anticancer drugs in world-wide clinical use so far. Volume 1 , Issue 2 , Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website. Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

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Neutron activation analysis for iridium, palladium and silver in platinum

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